LXR-dependent and -independent effects of oxysterols on immunity and tumor growth

摘要: Oxysterols are involved in maintaining cellular cholesterol levels. Recently, oxysterols have been demonstrated to modulate the function of immune cells and tumor growth. These effects can be dependent on activation oxysterol-binding liver X receptors (LXRs) or, as recently for T B cells, DCs neutrophils, independent LXR activation. LXR-dependent oxysterol ascribed LXRα, LXRβ or LXRαβ isoforms, which induces transcriptional trans-repression target genes. The prevalent one isoform seems cell-, tissue-, context-specific, shown some pathologic processes, i.e., infectious diseases, atherosclerosis, autoimmunity. Oxysterol-LXR signaling has inhibit antitumor responses, well cell Here, we review mechanisms that link growth, discuss possible networks at basis -independent development.