作者: Masako Oda , Yutaka Kanoh , Yoshihisa Watanabe , Hisao Masai
DOI: 10.1371/JOURNAL.PONE.0042375
关键词: Replication timing 、 DNA Replication Timing 、 Genetics 、 Origin recognition complex 、 Control of chromosome duplication 、 Replication factor C 、 Eukaryotic DNA replication 、 DNA replication factor CDT1 、 Pre-replication complex 、 Biology
摘要: Background Replication timing of metazoan DNA during S-phase may be determined by many factors including chromosome structures, nuclear positioning, patterns histone modifications, and transcriptional activity. It Mb-domain termed as “replication domains”, recent findings indicate that replication is under developmental cell type-specific regulation.