ATF6α-Rheb-mTOR signaling promotes survival of dormant tumor cells in vivo
作者： D. M. Schewe , J. A. Aguirre-Ghiso
关键词: Protein kinase B 、 Dormancy 、 Cell culture 、 Cancer research 、 RHEB 、 Squamous carcinoma 、 Cell biology 、 In vivo 、 Cancer cell 、 Transcription factor 、 Biology
摘要: The pathways that allow quiescent disseminated cancer cells to survive during prolonged dormancy periods are unknown. Here, we identify the transcription factor ATF6α as a pivotal survival for but not proliferative squamous carcinoma cells. is essential adaptation of dormant chemotherapy, nutritional stress, and, most importantly, in vivo microenvironment. Mechanism analysis showed MKK6 and p38α/β contribute regulating nuclear translocation transcriptional activation Downstream, induces through up-regulation Rheb mTOR signaling independent Akt. Down-regulation or reverted tumor cell resistance rapamycin induced pronounced killing only vivo. Knocking down also nude mice bearing Targeting by ATF6α-Rheb-mTOR pathway may favor eradication residual disease periods.
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