Induction of Krüppel-Like Factor 5 Expression by Androgens Results in Increased CXCR4-Dependent Migration of Prostate Cancer Cells in Vitro

摘要: Advanced prostate cancers preferentially metastasize to bone, suggesting that this tissue produces factors provide a suitable microenvironment for cancer cells. Recently, it has become clear even in antiandrogen-resistant cancers, the androgen receptor (AR)-signaling axis is required progression. Therefore, we hypothesized AR may be involved regulation of pathways are responsible homing cells select microenvironments. In support hypothesis, have determined chemokine (C-X-C motif) 4 (CXCR4), CXCL12, up-regulated response androgens. Given levels CXCL12 elevated at sites known metastases such as these results suggest androgens influence metastasis. Specifically, demonstrate increase both CXCR4 mRNA and functional protein LNCaP ...