The mitochondria-targeted anti-oxidant mitoquinone decreases liver damage in a phase II study of hepatitis C patients.
作者： Edward J. Gane , Frank Weilert , David W. Orr , Geraldine F. Keogh , Michael Gibson
DOI: 10.1111/J.1478-3231.2010.02250.X
关键词: Oxidative stress 、 Viral load 、 Virology 、 Pharmacology 、 Ribavirin 、 MitoQ 、 Hepatitis C 、 Alanine transaminase 、 Steatohepatitis 、 Biology 、 Pegylated interferon
摘要: … investigated the effect of oral mitoquinone on serum … mitoquinone groups compared with placebo did not reach significance (P>0.05). There was no change in HCV load on mitoquinone …
cabdirect.org
blackwell-synergy.com参考文章(30)
Sumio Watanabe, Reiko Yaginuma, Kenichi Ikejima, Akihisa Miyazaki, Liver diseases and metabolic syndrome Journal of Gastroenterology. ,vol. 43, pp. 509- 518 ,(2008) , 10.1007/S00535-008-2193-6
T. Jake Liang, Barbara Rehermann, Leonard B. Seeff, Jay H. Hoofnagle, Pathogenesis, Natural History, Treatment, and Prevention of Hepatitis C Annals of Internal Medicine. ,vol. 132, pp. 296- 305 ,(2000) , 10.7326/0003-4819-132-4-200002150-00008
PAUL ANGULO, KEITH D LINDOR, Non-alcoholic fatty liver disease. Journal of Gastroenterology and Hepatology. ,vol. 17, ,(2002) , 10.1046/J.1440-1746.17.S1.10.X
Patrick Marcellin, Hepatitis B and hepatitis C in 2009 Liver International. ,vol. 29, pp. 1- 8 ,(2009) , 10.1111/J.1478-3231.2008.01947.X
Daniel Lavanchy, The global burden of hepatitis C. Liver International. ,vol. 29, pp. 74- 81 ,(2009) , 10.1111/J.1478-3231.2008.01934.X
Miriam J. Alter, Hepatitis C virus infection in the United States Journal of Hepatology. ,vol. 31, pp. 88- 91 ,(1999) , 10.1016/S0168-8278(99)80381-X
Geoffrey F. Kelso, Carolyn M. Porteous, Carolyn V. Coulter, Gillian Hughes, William K. Porteous, Elizabeth C. Ledgerwood, Robin A. J. Smith, Michael P. Murphy, Selective Targeting of a Redox-active Ubiquinone to Mitochondria within Cells: ANTIOXIDANT AND ANTIAPOPTOTIC PROPERTIES * Journal of Biological Chemistry. ,vol. 276, pp. 4588- 4596 ,(2001) , 10.1074/JBC.M009093200
Edward Gane, Helen Pilmore, Management of chronic viral hepatitis before and after renal transplantation. Transplantation. ,vol. 74, pp. 427- 437 ,(2002) , 10.1097/00007890-200208270-00001
Deborah L. Diamond, Jon M. Jacobs, Bryan Paeper, Sean C. Proll, Marina A. Gritsenko, Robert L. Carithers, Anne M. Larson, Matthew M. Yeh, David G. Camp, Richard D. Smith, Michael G. Katze, Proteomic profiling of human liver biopsies: hepatitis C virus-induced fibrosis and mitochondrial dysfunction. Hepatology. ,vol. 46, pp. 649- 657 ,(2007) , 10.1002/HEP.21751
Harald Farnik, Ulrike Mihm, Stefan Zeuzem, Optimal therapy in genotype 1 patients. Liver International. ,vol. 29, pp. 23- 30 ,(2009) , 10.1111/J.1478-3231.2008.01969.X