Dissociating scopolamine-induced disrupted and persistent latent inhibition: stage-dependent effects of glycine and physostigmine
作者： Segev Barak , Ina Weiner
DOI: 10.1007/S00213-010-1785-Z
关键词: Acetylcholine receptor 、 Latent inhibition 、 Conditioning 、 Muscarinic antagonist 、 Physostigmine 、 Stimulus (physiology) 、 Pharmacology 、 Muscarinic acetylcholine receptor 、 Chemistry 、 Psychosis
摘要: Rationale Latent inhibition (LI) is the poorer conditioning to a stimulus seen when preceded by repeated non-reinforced pre-exposure stimulus. LI indexes ability ignore irrelevant stimuli and used extensively model attentional impairments in schizophrenia. We showed that pro-psychotic muscarinic antagonist scopolamine can produce disruption or persistence depending on dose stage of administration: low doses disrupt acting procedure, whereas higher produces abnormally persistent via action stage. The two abnormalities show distinct response antipsychotic drugs (APDs), with disruption, but not persistence, reversed APDs.
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