Peanut Agglutinin, A New Mitogen That Binds to Galactosyl Sites Exposed after Neuraminidase Treatment

摘要: Peanut agglutinin, purified by affinity chromatography, agglutinates lymphocytes from mouse, rat, guinea pig, and man only after their treatment with neuraminidase. However, it stimulates neuraminidase-treated rat human cells. A similar number cell surface receptors for peanut agglutinin was found on mouse although the latter cells were not stimulated lectin. Galactose specifically inhibited agglutination stimulation of agglutinin. Sequential neuraminidase beta-galactosidase markedly reduced response to soybean galactose oxidase. It is suggested that same galactosyl residue may be target initial step in triggering above mentioned mitogens.