Granulocyte colony-stimulating factor: Molecular mechanisms of action during steady state and ‘emergency’ hematopoiesis

摘要: Neutrophils are phagocytes whose principal function is to maintain anti-bacterial immunity. ingest and kill invading bacteria, releasing cytotoxic, chemotactic inflammatory mediators at sites of infection. This serves control the immediate host immune response attract other cells, such as macrophages dendritic which important for establishing long-term adaptive thus contribute both initiation maintenance inflammation Aberrant neutrophil activity deleterious; suppressed responses can cause extreme susceptibility infection while overactivation lead excessive tissue damage. review will focus on regulation by granulocyte colony-stimulating factor (G-CSF), cytokine controlling development function. The emphasize molecular aspects G-CSF-driven granulopoiesis in steady state (healthy) conditions during demand-driven or 'emergency' elicited clinical administration G-CSF. Understanding aid new approaches designed treat disorders production