The effect of chitosan hydrogen bonding on lactose crystallinity during spray drying

作者: Mona Edrisi Sormoli , Md Imtiaz Ul Islam , T.A.G. Langrish

DOI: 10.1016/J.JFOODENG.2011.09.011

关键词: ChitosanOrganic chemistryCrystallizationSpray dryingMaterials scienceLactoseCrystallinityDifferential scanning calorimetryPolyethylene glycolChemical engineeringGlass transition

摘要: Abstract The effect of chitosan on the crystallization behavior lactose has been studied during spray drying lactose/chitosan solutions. Solutions with different ratios and have dried at an inlet temperature 160 °C using a laboratory-scale dryer. Water-induced crystallization, X-ray diffraction analysis differential scanning calorimetry used to study crystallinity spray-dried powders. Results show that, despite ability retain moisture for longer time drying, powders were in amorphous form. Moisture-induced results suggest that presence delays crystallization. This finding may be due high glass-transition chitosan, its hydrogen bond water, which was suggested previously by other researchers reason crystallizing polyethylene glycol.

参考文章(43)
J.J. Fitzpatrick, M. Hodnett, M. Twomey, P.S.M. Cerqueira, J. O'Flynn, Y.H. Roos, Glass transition and the flowability and caking of powders containing amorphous lactose Powder Technology. ,vol. 178, pp. 119- 128 ,(2007) , 10.1016/J.POWTEC.2007.04.017
Md. Kamrul Haque, Yrjö H. Roos, Differences in the physical state and thermal behavior of spray-dried and freeze-dried lactose and lactose/protein mixtures Innovative Food Science & Emerging Technologies. ,vol. 7, pp. 62- 73 ,(2006) , 10.1016/J.IFSET.2004.12.004
Jerzy Zawadzki, Halina Kaczmarek, Thermal treatment of chitosan in various conditions Carbohydrate Polymers. ,vol. 80, pp. 394- 400 ,(2010) , 10.1016/J.CARBPOL.2009.11.037
Erwin Mayer, G. P. Johari, Andreas Hallbrucker, The glass–liquid transition of hyperquenched water Nature. ,vol. 330, pp. 552- 553 ,(1987) , 10.1038/330552A0
Shaojie Lu, Xuefeng Song, Deyong Cao, Yiping Chen, Kangde Yao, Preparation of water-soluble chitosan Journal of Applied Polymer Science. ,vol. 91, pp. 3497- 3503 ,(2004) , 10.1002/APP.13537
N. Drapier-Beche, J. Fanni, M. Parmentier, M. Vilasi, Evaluation of lactose crystalline forms by nondestructive analysis Journal of Dairy Science. ,vol. 80, pp. 457- 463 ,(1997) , 10.3168/JDS.S0022-0302(97)75957-5
BFd Oliveira, MHA Santana, Maria Inês Ré, Spray-dried chitosan microspheres cross-linked with d, l-glyceraldehyde as a potential drug delivery system: preparation and characterization Brazilian Journal of Chemical Engineering. ,vol. 22, pp. 353- 360 ,(2005) , 10.1590/S0104-66322005000300004
Rangika Weerakody, Peter Fagan, Shantha L. Kosaraju, Chitosan microspheres for encapsulation of α-lipoic acid International Journal of Pharmaceutics. ,vol. 357, pp. 213- 218 ,(2008) , 10.1016/J.IJPHARM.2008.02.019