COUP-TFII in pancreatic adenocarcinoma: Clinical implication for patient survival and tumor progression

摘要: Despite the accumulating knowledge of alterations in pancreatic cancer molecular pathways, no substantial improvements clinical prognosis have been made and this malignancy continues to be a leading cause death Western World. The orphan nuclear receptor COUP-TFII is regulator wide range biological processes it may exert pro-oncogenic role cells; interestingly, indirect evidences suggest that could involved cancer. aim study was evaluate expression human tumors unveil its regulation tumor growth. We evaluated by immunohistochemistry on primary samples. analyzed effect silencing cells means shRNA expressing cell lines. finally confirmed vitro results vivo experiments nude mice. expressed 69% tested samples correlates with N1 M1 status stage; Kaplan-Meier Cox regression analysis show an independent prognostic factor worst outcome. In reduces growth invasiveness strongly inhibits angiogenesis, mediated VEGF-C. mice, 40%. Our might important behavior adenocarcinoma, thus representing possible new target for therapy.