THE EFFECT OF ADRENALECTOMY AND HYDROCORTISONE ON RESPONSES TO NOREPINEPHRINE AND STIMULATION OF THE CARDIOACCELERATOR NERVE

摘要: The influence of the lack and an excess adrenal cortical hormones on chronotropic pressor responses to exogenously administered endogenously released norepinephrine (NE) has been examined in two types experiments dogs. In one type experiment intravenous NE cardiac sympathetic nerve stimulation were measured six adrenalectomized (10 days before experiment) dogs at least 60 min after 4.7 8.7 mg/kg hydrocortisone. Responses compared with those seen a control group. second experiment, studied 10 30 120 either placebo or 50 absence corticoids did not alter nerve-released NE. These data suggest that vivo cardiovascular catecholamines overemphasized.