Treatment of osteoarthritis with a once-daily dosing regimen of celecoxib: a randomized, controlled trial

摘要: A previous study has shown celecoxib 100 mg b.i.d. to be comparably effective naproxen 500 in treating osteoarthritis (OA). The primary objective of this was compare the efficacy a once-daily regimen (200 q.d.) signs and symptoms OA. In double-blind, placebo-controlled, parallel-group, multicenter study, 686 patients with OA knee flare state were enrolled. Patients randomly assigned receive (N = 231), 200 q.d. 223), or placebo 232) for 6 weeks. Arthritis assessments performed at baseline weeks 2 6, early termination. all measurements efficacy, assessments, improvements from both groups statistically superior those group (p