Ceftazidime and amikacin alone and in combination against Pseudomonas aeruginosa and Enterobacteriaceae.
作者： Julia A. Moody , Claudine E. Fasching , Lance R. Peterson , Dale N. Gerding
DOI: 10.1016/0732-8893(87)90115-5
关键词: Microbiology 、 Enterobacteriaceae 、 Amikacin 、 Ceftazidime 、 In vivo 、 Inoculation 、 Antimicrobial 、 Pseudomonas aeruginosa 、 Biology 、 Colony-forming unit
摘要: Abstract The efficacy of ceftazidime alone and combined with amikacin was studied in a rabbit model simulating closed-space infections at locally neutropenic sites. Six strains Pseudomonas aeruginosa, six Enterobacteriaceae (two each Klebsiellapneumoniae Serratiamarcescens one strain Escherichiacoli Citrobacterfreundii) pooled serum were inoculated into separate subcutaneous semipermeable chambers. Intramuscular antibiotic therapy begun 4 hr later (50 mg/kg) (15 for or (100 pseudomonads every 6 16 doses. Amikacin ineffective all 12 strains. Ceftazidime successful (⩾5.5 log 10 colony forming units (CFU)/ml decrease from drug-free control) eliminating five but not against any the pseudomonads. plus same best vitro tests prediction vivo outcome high inoculum (⩾7 CFU/ml) susceptibility, checkerboard synergism testing, conventional time-kill rates concentrations antimicrobials extravascular levels obtained vivo.
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