Apigenin enhances the antitumor effects of cetuximab in nasopharyngeal carcinoma by inhibiting EGFR signaling
作者： Wen-Jian Hu , Jing Liu , Lun-Kun Zhong , Jian Wang
DOI: 10.1016/J.BIOPHA.2018.03.111
关键词: Apigenin 、 In vivo 、 Nasopharyngeal carcinoma 、 Epidermal growth factor receptor 、 Cyclin D1 、 Cetuximab 、 Cancer research 、 Radiation therapy 、 Chemotherapy 、 Medicine
摘要: Nasopharyngeal carcinoma (NPC) is a type of head and neck cancers with poor prognosis. Despite that platinum-based chemotherapy concurrent radiotherapy have made great achievements for the treatment NPC, therapeutic reaction toxicity varies dramatically among individuals. Apigenin (API), naturally occurring plant flavone, considered to anti-cancer effect. Cetuximab (CET), well known epidermal growth factor receptor (EGFR) inhibitor, widely used in various cancers, especially cancers. The aim our study was measure combination API CET NPC vitro vivo. Results demonstrated combining could better suppress viability human nasopharyngeal cell lines (HONE1 CNE2) inhibit than or alone. Besides, produced greater pro-apoptosis Moreover, increased G2/M phase arrest caused by be remarkably enhanced adding HONE1 CNE2 cells. Although, both decrease expressions p-EGFR, p-Akt, p-STAT3 Cyclin D1. Combining them inhibition These results suggested may promising approach NPC.
sci-hub.se 参考文章(31)
F Yin, A E Giuliano, R E Law, A J Van Herle, Apigenin inhibits growth and induces G2/M arrest by modulating cyclin-CDK regulators and ERK MAP kinase activation in breast carcinoma cells. Anticancer Research. ,vol. 21, pp. 413- 420 ,(2001)
Jacques Ferlay, Isabelle Soerjomataram, Rajesh Dikshit, Sultan Eser, Colin Mathers, Marise Rebelo, Donald Maxwell Parkin, David Forman, Freddie Bray, Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012. International Journal of Cancer. ,vol. 136, ,(2015) , 10.1002/IJC.29210
Md. Asaduzzaman Sikder, Hyun Jae Lee, Jiho Ryu, Su Hyun Park, Ju-Ock Kim, Jang-Hee Hong, Jeong Ho Seok, Choong Jae Lee, Apigenin and Wogonin Regulate Epidermal Growth Factor Receptor Signaling Pathway Involved in MUC5AC Mucin Gene Expression and Production from Cultured Airway Epithelial Cells Tuberculosis and Respiratory Diseases. ,vol. 76, pp. 120- 126 ,(2014) , 10.4046/TRD.2014.76.3.120
Brigette BY Ma, Terence CW Poon, KF To, Benny Zee, Frankie KF Mo, Charles ML Chan, Stephen Ho, Peter ML Teo, Phillip J Johnson, Anthony TC Chan, None, Prognostic significance of tumor angiogenesis, Ki 67, p53 oncoprotein, epidermal growth factor receptor and HER2 receptor protein expression in undifferentiated nasopharyngeal carcinoma - A prospective study Head and Neck-journal for The Sciences and Specialties of The Head and Neck. ,vol. 25, pp. 864- 872 ,(2003) , 10.1002/HED.10307
Doris Mangelberger, Daniela Kern, Andrea Loipetzberger, Markus Eberl, Fritz Aberger, Cooperative Hedgehog-EGFR signaling. Frontiers in Bioscience. ,vol. 17, pp. 90- 99 ,(2012) , 10.2741/3917
Naseem Ghazali, Richard J. Shaw, Simon N. Rogers, Janet M. Risk, Genomic determinants of normal tissue toxicity after radiotherapy for head and neck malignancy: A systematic review Oral Oncology. ,vol. 48, pp. 1090- 1100 ,(2012) , 10.1016/J.ORALONCOLOGY.2012.08.002
MING QIAN, DONGHUA QIAN, HONGYU JING, YANG LI, CHENGYUAN MA, YANMIN ZHOU, Combined cetuximab and celecoxib treatment exhibits a synergistic anticancer effect on human oral squamous cell carcinoma in vitro and in vivo. Oncology Reports. ,vol. 32, pp. 1681- 1688 ,(2014) , 10.3892/OR.2014.3334
Laura Masuelli, Laura Marzocchella, Alessandro Quaranta, Camilla Palumbo, Giorgio Pompa, Valerio Izzi, Antonella Canini, Andrea Modesti, Fabio Galvano, Roberto Bei, Apigenin induces apoptosis and impairs head and neck carcinomas EGFR/ErbB2 signaling Frontiers in Bioscience. ,vol. 16, pp. 1060- 1068 ,(2011) , 10.2741/3735
Carolien Boeckx, Ken Op de Beeck, An Wouters, Vanessa Deschoolmeester, Ridha Limame, Karen Zwaenepoel, Pol Specenier, Patrick Pauwels, Jan B. Vermorken, Marc Peeters, Guy Van Camp, Marc Baay, Filip Lardon, Overcoming cetuximab resistance in HNSCC: The role of AURKB and DUSP proteins Cancer Letters. ,vol. 354, pp. 365- 377 ,(2014) , 10.1016/J.CANLET.2014.08.039
A. W. M. Lee, S. Y. Tung, D. T. T. Chua, R. K. C. Ngan, R. Chappell, R. Tung, L. Siu, W. T. Ng, W. K. Sze, G. K. H. Au, S. C. K. Law, B. O'Sullivan, T. K. Yau, T. W. Leung, J. S. K. Au, W. M. Sze, C. W. Choi, K. K. Fung, J. T. Lau, W. H. Lau, Randomized Trial of Radiotherapy Plus Concurrent–Adjuvant Chemotherapy vs Radiotherapy Alone for Regionally Advanced Nasopharyngeal Carcinoma Journal of the National Cancer Institute. ,vol. 102, pp. 1188- 1198 ,(2010) , 10.1093/JNCI/DJQ258