Efficacy of a polyethylene oxide-sodium carboxymethylcellulose gel in prevention of intrauterine adhesions after hysteroscopic surgery.
作者： Attilio Di Spiezio Sardo , Marialuigia Spinelli , Silvia Bramante , Marianna Scognamiglio , Elena Greco
DOI: 10.1016/J.JMIG.2011.04.007
关键词: Medicine 、 Polyethylene oxide 、 Endometrial ablation 、 Hysteroscopic surgery 、 Surgery 、 Sodium carboxymethylcellulose 、 Prospective cohort study 、 Hysteroscopy 、 Randomized controlled trial 、 Dysfunctional uterine bleeding
摘要: Abstract Study Objectives To assess the efficacy of a polyethylene oxide–sodium carboxymethylcellulose gel (Intercoat; Gynecare, division Ethicon, Inc., Somerville, NJ) in preventing development de novo intrauterine adhesions (IUAs) after hysteroscopic surgery and to rate patency internal uterine ostium at 1-month follow-up diagnostic hysteroscopy. Design Randomized controlled study (Canadian Task Force classification I). Setting University hospital. Patients One hundred ten patients diagnosed during office hysteroscopy as having single or multiple lesions suitable for surgical treatment resistant dysfunctional bleeding requiring endometrial ablation. Interventions were randomized 2 groups. Group 1 underwent plus application Intercoat gel, group only (control group). Follow-up was performed month severity IUA formation intervention. Measurements Main Results Compared with 2, demonstrated significant reduction incidence (6% vs 22%; p Conclusions seems prevent IUAs improve However, larger studies are needed confirm these findings.
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