PIM1 kinase as a promise of targeted therapy in prostate cancer stem cells.
作者： YINGQIU XIE , SAMAT BAYAKHMETOV
DOI: 10.3892/MCO.2015.673
关键词: Stem cell 、 Targeted therapy 、 Cancer cell 、 Suicide gene 、 Cancer 、 Carcinogenesis 、 Biology 、 Prostate cancer 、 Cancer stem cell 、 Cancer research
摘要: Since the last decade, PIM family serine/threonine kinases have become a focus in cancer research. Numerous clinical data supports that overexpression of PIM1 is associated with tumor formation various tissues. However, little known regarding function stem cells. In cells, has essential roles regulation cell cycle, proliferation, survival and multiple drug resistance. kinase exhibits significant self-renewal expansion. Thus, shows great promise therapy by targeting Furthermore, it imperative to investigate Pim-1 cells applicable inhibitors for improving future outcomes. The present review investigated potential as target prostate
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