Inadvertent Relaxation of the Ductus Arteriosus by Pharmacologic Agents that are Commonly Used in the Neonatal Period
作者： Jeff Reese , Alex Veldman , Lisa Shah , Megan Vucovich , Robert B. Cotton
DOI: 10.1053/J.SEMPERI.2010.02.007
关键词: Relaxation (psychology) 、 Maturation process 、 Ductus arteriosus 、 Cardiology 、 Heparin 、 Conservative management 、 Aminoglycoside 、 Medicine 、 Internal medicine 、 DUCTUS ARTERIOSUS PATENT 、 Anesthesia 、 Premature birth 、 Obstetrics and gynaecology 、 Pediatrics, Perinatology, and Child Health
摘要: Premature birth and disruption of the normal maturation process leave immature ductus arteriosus unable to respond postnatal cues for closure. Strategies that advocate conservative management patent (PDA) in premature infants are dependent on identification symptomatic PDA understanding risk factors predispose PDA. Exposure unintended vasodilatory stimuli may be one is underrecognized. In this article, we summarize clinical associated with review commonly used neonatal drugs their properties. Data demonstrating relaxation by gentamicin other aminoglycoside antibiotics, cimetidine H2 receptor antagonists, heparin provided as examples therapies have unanticipated effects promote
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