Regulation of Macrophage Polarity by HDL, Apolipoproteins, and Apolipoprotein Mimetic Peptides

摘要: Macrophages are a versatile and heterogeneous group of cells which vary in phenotype function. M1-polarized macrophages play key role the host defense response via production inflammatory mediators cytokines. The concept macrophage plasticity proposes that these can be reprogrammed to an alternatively activated, M2-polarized state, thus allowing conversion initial one wound healing repair. focus this chapter is discuss mechanisms by high-density lipoprotein (HDL) modulates Specifically, recent studies discussed suggesting HDL reduces tissue injury inducing undergo M2 polarization. This may mediated both HDL-associated lipids proteins. We additionally review apolipoprotein A-I mimetic peptides replicate effects on