Hydrocarbon Stapled Antimicrobial Peptides.
作者： Dorian Migoń , Damian Neubauer , Wojciech Kamysz
DOI: 10.1007/S10930-018-9755-0
关键词: Cross-Linking Reagents 、 Antimicrobial peptides 、 Antimicrobial 、 Peptide 、 Combinatorial chemistry 、 Biological activity 、 Protein secondary structure 、 Bioorganic chemistry 、 Chemistry 、 Chemical stability
摘要: Antimicrobial peptides are promising candidates for anti-infective pharmaceuticals. Unfortunately, because of their low proteolytic and chemical stability, usage is generally narrowed down to topical formulations. Until now, numerous approaches increase peptide stability have been proposed. One them, hydrocarbon stapling, a modification based on stabilizing secondary structure with side-chain covalent bridge, successfully applied many peptides. Moreover, constraining also proven biological activity. This review article describes studies stapled antimicrobial respect improved drug-like properties.
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