Functional pathology of human ovarian steroidogenesis: Normal cycling ovary and steroid-producing neoplasms.

摘要: In human reproductive endocrinology and pathology, it is important to localize the sites of steroid hormone production obtain a better understanding metabolism. Previous approaches, including morphological biological studies, could not sufficiently demonstrate which cells produce what steroids in both normal pathological ovaries. Recent development immunohistochemistry situ hybridization enzymes specifically involved sex biosynthesis made possible detect expression steroidogenic enzymes, subsequently specific diagnostic pathology materials. There are, however, some limitations correlation findings with preoperative systemic hormonal manifestations patients cord-stromal tumors ovary, great care should be taken when interpreting results.