Mapping the collaterome for precision cerebrovascular health: Theranostics in the continuum of stroke and dementia.

摘要: Precision cerebrovascular health or individualized long-term preservation of the brain and associated blood vessels, is predicated on understanding, diagnosing, tailoring therapies for people at risk ischemic injury with stroke vascular dementia. The imaging patterns are sculpted by protective effect collaterome, innate compensatory ability vasculature to offset hypoperfusion when antegrade normal arterial inflow pathways compromised. Theranostics rational synchronous use diagnostic studies in tandem specific optimally guide patient outcomes disorders may capitalize pivotal role collaterome. Understanding functional impact collaterome across populations individuals would advance translational science brain, while questions immediate clinical implications be prioritized. Big data systematic analyses necessary develop normative standards, multimodal atlases, delineation management. Large-scale, provide a platform work cerebral collateral circulation hemodynamics theranostic framework direct implications. This article frames incipient research objectives precision medicine coming years, building upon concept health.