RELEASE OF [3H]NORADRENALINE AND [3H]DOPAMINE FROM FIELD STIMULATED CEREBRAL CORTEX SLICES EFFECT OF TYROSINE HYDROXYLASE AND DOPAMINE-β-HYDROXYLASE INHIBITION.1
作者： L.-O. Farnebo , B. Hamberger , G. Jonsson
DOI: 10.1111/J.1471-4159.1971.TB00205.X
关键词: Tyrosine hydroxylase 、 Dopamine 、 Cerebral cortex 、 Tyrosine Hydroxylase Inhibitor 、 Internal medicine 、 Stimulation 、 Endocrinology 、 In vitro 、 Incubation 、 Endogeny 、 Chemistry
摘要: — Rat cerebral cortex slices were incubated in vitro with [3H]dopamine (DA) or [3H]noradrenaline (NA) (10−7M), superfused by fresh buffer and stimulated an electric field. The stimulation-induced overflow of [3H]DA [3H]NA was determined. In from untreated rats about 16 ng [3H]NA/g tissue formed [3H]DA, corresponding to 5 per cent the endogenous NA concentration. Stimulation markedly enhanced [3H]NA. newly overflowing a greater extent than previously taken up incubation medium, indicating preferential release synthesized transmitter. increased pretreated tyrosine hydroxylase inhibitor (H44/68). It seems that depletion stores central neurons inhibition makes [3H]cate-cholamines more available for release. Pretreatment DA-β-hydroxylase inhibitors FLA63 FLA69 considerably diminished formation [3H]DA. DA can act as ‘false transmitter’ after inhibition.
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