Modulation of apoptosis by human papillomavirus (HPV) oncoproteins.

摘要: The regulation of host-mediated apoptosis by the E6 and E7 oncoproteins has garnered attention because it is believed to be an important strategy employed high-risk (HR)-human papillomaviruses (HPVs) evade immune surveillance. Additionally, revelation that E5 can protect cells from tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-mediated suggests may also play a role in undermining host defense mechanisms. Cellular transformation unintended consequence persistent infection HR-HPVs, therefore likely primary function E5, regulate cell survival throughout normal viral life cycle order ensure replication promote spread progeny. purpose this article review literature on describes mechanisms HR-HPVs persist create conditions necessary for cellular transformation.