Cloning and expression pattern of a mouse homologue of Drosophila sprouty in the mouse embryo
作者： Alice Anne de Maximy , Yuhki Nakatake , Stephane Moncada , Nobuyuki Itoh , Jean Paul Thiery
DOI: 10.1016/S0925-4773(98)00241-X
关键词: Nasal placode 、 Biology 、 SPRY2 、 Mesenchyme 、 Primitive streak 、 Genetics 、 Cell signaling 、 Paraxial mesoderm 、 Cell biology 、 Days post coitum 、 Fibroblast growth factor
摘要: Signaling molecules belonging to the Fibroblast growth factor (Fgf) family are necessary for directing bud outgrowth during tracheal development in Drosophila and lung mouse. A potential inhibitor of Fgf signaling pathway, called Sprouty, has been identified Drosophila. We have three mouse homologues ofsprouty. One them, Sprouty4, exhibits a very restricted expression pattern. At 8.0 dpc (days post coitum) Sprouty4 is strongly expressed primitive streak region. 9.5 10.5 dpc, nasal placode, maxillary mandibular processes, otic vesicule, second branchial arch, progress region limb buds presomitic mesoderm. also detected lateral somites. In developing lung, broadly distal mesenchyme. © 1999 Elsevier Science Ireland Ltd. All rights reserved.
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