Defining the Potential of MSCs with a Prenatal Large Animal Model

摘要: An experimental model system that allows the assessment of full ­differentiative potential human mesenchymal stromal/stem cells (MSC) under normal physiological conditions, in absence genetic or injury-induced ­dysfunction, could reveal their true capabilities and also provide a valuable tool to dissect pathways governing differentiation fate reprogramming. The naturally occurring stem cell migratory patterns, availability expanding homing engraftment sites, presence tissue/organ-specific signals combine make developing mammalian fetus an ideal setting for MSCs display biological potential. In addition these characteristics, early gestational age possesses unique advantage being relatively immunologically naive, making it possible achieve long-term persistence other from not only allogeneic but xenogeneic donors as well. this chapter, we describe advantages pre-immune studying discuss results have obtained thus far with large animal (sheep) fetal model.