Scanning Electron Microscopy of Subclinical Gefitinib-Induced Hair Changes.

摘要: Oral inhibitors of epidermal growth factor receptor may have a wide range cutaneous manifestations. Hair manifestations are observed in 10%-20% the patients. At ultrastructural level erlotinib-induced hair changes were already described as acquired pili torti et canaliculi. We examined 78-year-old female patient, with lung carcinoma, taking gefitinib for 15 months. The treatment has no side effects good tolerance and tumor response. Although patient had not any change on hairs under therapy, some specimens obtained to be natura scanning electron microscopy. Under low magnification incipient grooving was surface, tortions or angulations shaft found. With higher magnifications surface even more evident. Our findings show that cause subclinical changes, similar those at erlotinib.