Biology and pathophysiology of the new human retrovirus XMRV and its association with human disease.
作者： Alice Rusmevichientong , Samson A. Chow
DOI: 10.1007/S12026-010-8165-Y
关键词: Chronic fatigue syndrome 、 Immunology 、 Human disease 、 Virus 、 Pathophysiology 、 Prostate cancer 、 Retrovirus 、 Leukemia 、 Biology 、 Virology 、 Healthy individuals
摘要: Xenotropic murine leukemia virus-related virus (XMRV) is a new human retrovirus originally identified in prostate cancer patients with deficiency the antiviral enzyme RNase L. XMRV has been detected varying frequencies cases of and chronic fatigue syndrome (CFS), as well small proportion healthy individuals. An etiologic link between infection disease, however, yet to be established. Here, we summarize existing knowledge regarding characteristics replication, association CFS, potential mechanisms pathophysiology. We also highlight several areas, such establishment standardized assays development animal models, future directions advance our current understanding its relevance disease.
springer.com
sci-hub.se 参考文章(104)
Emily C. Knouf, Michael J. Metzger, Patrick S. Mitchell, Jason D. Arroyo, John R. Chevillet, Muneesh Tewari, A. Dusty Miller, Multiple Integrated Copies and High-Level Production of the Human Retrovirus XMRV (Xenotropic Murine Leukemia Virus-Related Virus) from 22Rv1 Prostate Carcinoma Cells Journal of Virology. ,vol. 83, pp. 7353- 7356 ,(2009) , 10.1128/JVI.00546-09
Robert J. Suhadolnik, Nancy L. Reichenbach, Patricia Hitzges, Robert W. Sobol, Daniel L. Peterson, Berch Henry, Dharam V. Ablashi, Werner E. G. Müller, Heinz C. Schröder, William A. Carter, David R. Strayer, Upregulation of the 2-5A Synthetase/RNase L Antiviral Pathway Associated with Chronic Fatigue Syndrome Clinical Infectious Diseases. ,vol. 18, ,(1994) , 10.1093/CLINIDS/18.SUPPLEMENT_1.S96
Harriet CT Groom, Virginie C Boucherit, Kerry Makinson, Edward Randal, Sarah Baptista, Suzanne Hagan, John W Gow, Frank M Mattes, Judith Breuer, Jonathan R Kerr, Jonathan P Stoye, Kate N Bishop, Absence of xenotropic murine leukaemia virus-related virus in UK patients with chronic fatigue syndrome. Retrovirology. ,vol. 7, pp. 10- 10 ,(2010) , 10.1186/1742-4690-7-10
Jangsuk Oh, Kevin W. Chang, Stephen H. Hughes, Mutations in the U5 sequences adjacent to the primer binding site do not affect tRNA cleavage by rous sarcoma virus RNase H but do cause aberrant integrations in vivo. Journal of Virology. ,vol. 80, pp. 451- 459 ,(2006) , 10.1128/JVI.80.1.451-459.2006
Sushma Bhosle, Suganthi Suppiah, Ross Molinaro, Yuying Liang, Rebecca Arnold, William Diehl, Natalia Makarova, Jerry Blackwell, John Petros, Dennis Liotta, Eric Hunter, Hinh Ly, Evaluation of Cellular Determinants Required for In Vitro Xenotropic Murine Leukemia Virus-Related Virus Entry into Human Prostate Cancer and Noncancerous Cells Journal of Virology. ,vol. 84, pp. 6288- 6296 ,(2010) , 10.1128/JVI.00274-10
Gerald R Cunha, Will Ricke, Axel Thomson, Paul C Marker, Gail Risbridger, Simon W Hayward, YZ Wang, Annemarie A Donjacour, Takeshi Kurita, None, Hormonal, cellular, and molecular regulation of normal and neoplastic prostatic development The Journal of Steroid Biochemistry and Molecular Biology. ,vol. 92, pp. 221- 236 ,(2004) , 10.1016/J.JSBMB.2004.10.017
Konstantin Taganov, René Daniel, Richard A. Katz, Olga Favorova, Anna Marie Skalka, Characterization of retrovirus-host DNA junctions in cells deficient in nonhomologous-end joining. Journal of Virology. ,vol. 75, pp. 9549- 9552 ,(2001) , 10.1128/JVI.75.19.9549-9552.2001
Jason J. Rodriguez, Stephen P. Goff, Xenotropic Murine Leukemia Virus-Related Virus Establishes an Efficient Spreading Infection and Exhibits Enhanced Transcriptional Activity in Prostate Carcinoma Cells Journal of Virology. ,vol. 84, pp. 2556- 2562 ,(2010) , 10.1128/JVI.01969-09
Nicole Fischer, Olaf Hellwinkel, Claudia Schulz, Felix K.H. Chun, Hartwig Huland, Martin Aepfelbacher, Thorsten Schlomm, Prevalence of human gammaretrovirus XMRV in sporadic prostate cancer. Journal of Clinical Virology. ,vol. 43, pp. 277- 283 ,(2008) , 10.1016/J.JCV.2008.04.016
Sanggu Kim, Yein Kim, Teresa Liang, Janet S. Sinsheimer, Samson A. Chow, A High-Throughput Method for Cloning and Sequencing Human Immunodeficiency Virus Type 1 Integration Sites Journal of Virology. ,vol. 80, pp. 11313- 11321 ,(2006) , 10.1128/JVI.01737-06