Chromatin Assembly and Signalling the End of DNA Repair Requires Acetylation of Histone H3 on Lysine 56

摘要: The packaging of DNA into chromatin results in a barrier to all transactions. To facilitate transcription, replication and repair histone proteins are frequently post-translational modified. Such covalent additions residues can modulate folding and/or provide specificity docking surfaces for non-histone proteins. In the budding yeast, one such modification, transient acetylation H3 on residue lysine 56 (H3K56ac); occurs newly synthesized molecules facilitates their deposition onto replicated during S phase. H3K56ac also has role reassembly following damage Importantly, completion H3K56ac-dependent appears be required resumption cell proliferation after repair. Emerging evidence, although not without conflict, suggests that is only present human cells, but similarly regulated reassembly.