Folate-targeted diagnostics and treatment
作者： Christopher Paul Leamon , David Morgenstern , Richard Messmann
DOI:
关键词: Receptor 、 Internal medicine 、 Folate receptor 、 Lung cancer 、 Ovarian cancer 、 Platinum sensitive 、 Drug 、 Oncology 、 Conjugate 、 Medicine 、 Doxorubicin
摘要: Methods of detecting and assessing functionally active folate receptors on tumors treatment associated with those are described. Also described methods selecting ovarian lung cancer patients for therapy a folate-vinca conjugate by identifying the patient. compositions treating receptor expressing epithelial in combination doxorubicin such as pegylated liposomal which include ovarian, endometrial or non-small cell tumors, including platinum-resistant platinum sensitive tumors. using folate-targeted drug, absence presence patient
lens.org 参考文章(11)
Iontcho Radoslavov Vlahov, Apparao Satyam, Joseph Anand Reddy, Matthew A. Parker, Stephen J. Howard, Christopher Paul Leamon, Hari Krishna Santhapuram, Vitamin receptor binding drug delivery conjugates ,(2004)
Antoni Kozlowski, Samuel P. McManus, Stabilized polymeric thiol reagents ,(2005)
Christopher P. Leamon, Joseph A. Reddy, Iontcho R. Vlahov, Elaine Westrick, Nikki Parker, Jeffrey S. Nicoson, Marilynn Vetzel, Comparative preclinical activity of the folate-targeted Vinca alkaloid conjugates EC140 and EC145. International Journal of Cancer. ,vol. 121, pp. 1585- 1592 ,(2007) , 10.1002/IJC.22853
Levi S. Downs, Patricia L. Judson, Peter A. Argenta, Rahel Ghebre, Melissa A. Geller, Robin L. Bliss, Matthew P. Boente, William A. Nahhas, Samir Z. Abu-Ghazaleh, M. Dwight Chen, Linda F. Carson, A prospective randomized trial of thalidomide with topotecan compared with topotecan alone in women with recurrent epithelial ovarian carcinoma. Cancer. ,vol. 112, pp. 331- 339 ,(2008) , 10.1002/CNCR.23164
Timothy A. Yap, Craig P. Carden, Stan B. Kaye, Beyond chemotherapy: targeted therapies in ovarian cancer Nature Reviews Cancer. ,vol. 9, pp. 167- 181 ,(2009) , 10.1038/NRC2583
Sumith A Kularatne, Philip Stewart Low, Positron emission tomography imaging method ,(2005)
Iontcho Radoslavov Vlahov, Chunhong Li, Christopher Paul Leamon, Hari Krishna Santhapuram, Le-Cun Xu, Synthesis and purification of pteroic acid and conjugates thereof ,(2006)
R. E. Fisher, B. A. Siegel, S. L. Edell, N. M. Oyesiku, D. E. Morgenstern, R. A. Messmann, R. J. Amato, Exploratory Study of 99mTc-EC20 Imaging for Identifying Patients with Folate Receptor–Positive Solid Tumors The Journal of Nuclear Medicine. ,vol. 49, pp. 899- 906 ,(2008) , 10.2967/JNUMED.107.049478
Joseph A. Reddy, Ryan Dorton, Elaine Westrick, Alicia Dawson, Terri Smith, Le-Cun Xu, Marilynn Vetzel, Paul Kleindl, Iontcho R. Vlahov, Christopher P. Leamon, Preclinical Evaluation of EC145, a Folate-Vinca Alkaloid Conjugate Cancer Research. ,vol. 67, pp. 4434- 4442 ,(2007) , 10.1158/0008-5472.CAN-07-0033
E. Sausville, P. LoRusso, M. Quinn, K. Forman, C. Leamon, D. Morganstern, S. Bever, R. Messmann, A phase I study of EC145 administered weeks 1 and 3 of a 4-week cycle in patients with refractory solid tumors Journal of Clinical Oncology. ,vol. 25, pp. 2577- 2577 ,(2007) , 10.1200/JCO.2007.25.18_SUPPL.2577