Reply to: APP gene copy number changes reflect exogenous contamination.

Carlo Sala Frigerio, Pierre Lau, Claire Troakes, Vincent Deramecourt, Patrick Gele, Peter Van Loo, Thierry Voet, Bart De Strooper, On the identification of low allele frequency mosaic mutations in the brains of Alzheimer's disease patients Alzheimer's & Dementia. ,vol. 11, pp. 1265- 1276 ,(2015) , 10.1016/J.JALZ.2015.02.007

Diane M Bushman, Gwendolyn E Kaeser, Benjamin Siddoway, Jurgen W Westra, Richard R Rivera, Stevens K Rehen, Yun C Yung, Jerold Chun, Genomic mosaicism with increased amyloid precursor protein (APP) gene copy number in single neurons from sporadic Alzheimer's disease brains eLife. ,vol. 4, ,(2015) , 10.7554/ELIFE.05116

Gilad D. Evrony, Eunjung Lee, Bhaven K. Mehta, Yuval Benjamini, Robert M. Johnson, Xuyu Cai, Lixing Yang, Psalm Haseley, Hillel S. Lehmann, Peter J. Park, Christopher A. Walsh, Cell Lineage Analysis in Human Brain Using Endogenous Retroelements Neuron. ,vol. 85, pp. 49- 59 ,(2015) , 10.1016/J.NEURON.2014.12.028

Xuyu Cai, Gilad D. Evrony, Hillel S. Lehmann, Princess C. Elhosary, Bhaven K. Mehta, Annapurna Poduri, Christopher A. Walsh, Single-Cell, Genome-wide Sequencing Identifies Clonal Somatic Copy-Number Variation in the Human Brain Cell Reports. ,vol. 8, pp. 1280- 1289 ,(2014) , 10.1016/J.CELREP.2014.07.043

Gilad D Evrony, Xuyu Cai, Eunjung Lee, L Benjamin Hills, Princess C Elhosary, Hillel S Lehmann, JJ Parker, Kutay D Atabay, Edward C Gilmore, Annapurna Poduri, Peter J Park, Christopher A Walsh, None, Single-neuron sequencing analysis of L1 retrotransposition and somatic mutation in the human brain. Cell. ,vol. 151, pp. 483- 496 ,(2012) , 10.1016/J.CELL.2012.09.035

Jeffrey L Cummings, Travis Morstorf, Kate Zhong, Alzheimer's disease drug-development pipeline: few candidates, frequent failures Alzheimer's Research & Therapy. ,vol. 6, pp. 37- 37 ,(2014) , 10.1186/ALZRT269

Agnel Sfeir, Lorraine S. Symington, Microhomology-Mediated End Joining: A Back-up Survival Mechanism or Dedicated Pathway? Trends in Biochemical Sciences. ,vol. 40, pp. 701- 714 ,(2015) , 10.1016/J.TIBS.2015.08.006

Jennifer L. Hazen, Gregory G. Faust, Alberto R. Rodriguez, William C. Ferguson, Svetlana Shumilina, Royden A. Clark, Michael J. Boland, Greg Martin, Pavel Chubukov, Rachel K. Tsunemoto, Ali Torkamani, Sergey Kupriyanov, Ira M. Hall, Kristin K. Baldwin, The Complete Genome Sequences, Unique Mutational Spectra, and Developmental Potency of Adult Neurons Revealed by Cloning Neuron. ,vol. 89, pp. 1223- 1236 ,(2016) , 10.1016/J.NEURON.2016.02.004

Christopher S. von Bartheld, Jami Bahney, Suzana Herculano-Houzel, The search for true numbers of neurons and glial cells in the human brain: A review of 150 years of cell counting. The Journal of Comparative Neurology. ,vol. 524, pp. 3865- 3895 ,(2016) , 10.1002/CNE.24040

Junho Kim, Ju Heon Maeng, Jae Seok Lim, Hyeonju Son, Junehawk Lee, Jeong Ho Lee, Sangwoo Kim, Vecuum: identification and filtration of false somatic variants caused by recombinant vector contamination Bioinformatics. ,vol. 32, pp. 3072- 3080 ,(2016) , 10.1093/BIOINFORMATICS/BTW383