Orphanin FQ/nociceptin is a physiological regulator of prolactin secretion in female rats.
作者： Matthew Chesterfield , James Janik , Emily Murphree , Courtney Lynn , Erin Schmidt
DOI: 10.1210/EN.2006-0707
关键词: Nociceptin receptor 、 Endocrinology 、 Opioid 、 Endogenous opioid 、 Dopamine 、 Prolactin 、 Receptor 、 Internal medicine 、 Dopaminergic 、 Mechanism of action 、 Biology
摘要: Orphanin FQ/nociceptin (OFQ/N), the most recently identified endogenous opioid peptide, stimulates prolactin secretion in both male and female rats. OFQ/N, however, did not elicit this stimulatory effect through μ-, δ-, or κ-opiate receptor subtype. The role OFQ/N plays regulation under physiological conditions its mechanism of action are known. purpose these studies was to determine significance pharmacological specificity secretory response OFQ/N. In addition, tuberoinfundibular dopaminergic (TIDA) neurons mediating examined. Opioid receptor-like-1 (ORL-1) receptors were blocked by pretreatment with compound B (Comp B), a purported antagonist, synthesis disrupted ORL-1 antisense oligonucleotides. administration diestrous females measured. Furthermore, suckling-induced ...
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