Role of haeme oxygenase-1 in resolution of oxidative stress-related pathologies: focus on cardiovascular, lung, neurological and kidney disorders.

摘要: The present review examines the role of cytoprotective enzyme haeme oxygenase-1 (HO-1) in adaptive responses to inflammatory disease and explores strategies for its clinical use, with particular emphasis on use therapeutic using phytochemical inducers HO-1 such as extracts Ginkgo biloba, curcumin, flavonoids extracted from seeds sour cherry (Prunus cerasus). This laboratory has identified by which combinations dietary phytochemicals may be configured synergistically strengthen immunoregulatory mechanisms that normally prevent inflammation leading disease. A major focus this research initiative been HO-1, is capable substantially reducing oxidative stress several mechanisms. metabolizes accumulates tissues because red blood cell turnover. Two products degradation - carbon monoxide (CO) bilirubin have potent capacity counteracting effects. description will provided how maintain healthy tissue function remediate damage. explored four organ systems, including cardiovascular system, lungs, central nervous system kidneys. Particular given physiological coordination functions mediated CO produced nitric oxide (NO), a gaseous second messenger expressed synthetase. unifying theme an exploration potential formulations tools application reduction stressors, resultant improved treatment pathologies.