Gaucher's disease: a disease with chronic stimulation of the immune system.

摘要: Concentrations of IgA, IgG, and IgM were measured in 25 patients with Gaucher's disease. The mean each was significantly higher than that generally observed healthy adults. A direct correlation noted between IgA IgG concentrations age. Patients who underwent splenectomy had lower those persons did not. In two patients, multiple myeloma the nonsecretory type developed. migration inhibition factor (MIF) test performed lymphocytes our positive to glucocerebroside four 17 glucocerebrosidase 19 extracts spleen a patient disease three eight patients. results al MIF tests negative six control subjects splenomegaly other causes. Our suggest there is chronic stimulation humoral immune system. first expression this production polyclonal immunoglobulins and, due time, development monoclonal immunoglobulin as well myeloma.