Contemporary development in sequential Knoevenagel, Michael addition multicomponent reaction for the synthesis of 4-Aryl-5-oxo-5H-indeno [1,2-b]pyridine-3-carbonitrile
作者： Ajinkya A Patravale , Anil H Gore , Dipti R Patil , Govind B Kolekar , Madhukar B Deshmukh
DOI: 10.1007/S11164-015-2187-Y
关键词: Combinatorial chemistry 、 Michael reaction 、 Malononitrile 、 Catalysis 、 Aryl 、 Chemistry 、 Salt (chemistry) 、 Pyridine 、 Knoevenagel condensation
摘要: An uncatalyzed efficient synthesis of bioactive pyridine derivatives has been investigated for the first time by a three-component sequential multicomponent reaction tackled with aromatic aldehydes, malononitrile, and 1,3-indandione via Knoevenagel condensation followed Michael addition. The difference between domino is emphasized this methodology. proceeds at ambient temperature without frequently useful N-source like ammonium salt construction N-heterocycles, which makes protocol novel synthetic route preparation indenopyridine skeleton.
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