Acyl-coenzyme A:cholesterol acyltransferase 1 blockage enhances autophagy in the neurons of triple transgenic Alzheimer's disease mouse and reduces human P301L-tau content at the presymptomatic stage.
作者： Yohei Shibuya , Zhaoyang Niu , Elena Y. Bryleva , Brent T. Harris , Stephanie R. Murphy
DOI: 10.1016/J.NEUROBIOLAGING.2015.04.002
关键词: Microglia 、 Tau protein 、 Cell biology 、 Biochemistry 、 Autophagy 、 Presenilin 、 Amyloid precursor protein 、 Transgene 、 Tauopathy 、 Biology 、 Alzheimer's disease
摘要: … , ACAT1 blockage increases autophagosome formation and stimulates amyloid β peptide1-42 degradation. Here, we hypothesize that in neurons ACAT1 … , Acat1 KO stimulates TFEB-…
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