Interaction of Body Mass Index and Diabetes as Modifiers of Cardiovascular Mortality in a Cohort Study

摘要: OBJECTIVES Diabetes and obesity each increases mortality, but recent papers have shown that lean Asian persons were at greater risk for mortality than obese persons. The objective of this study is to determine whether an interaction exists between body mass index (BMI) diabetes, which can modify the death by cardiovascular disease (CVD). METHODS Subjects who over 20 years age, had information regarding BMI, past history fasting blood glucose levels (n=16 048), selected from Korea Multi-center Cancer Cohort participants. By 2008, a total 1290 participants died; 251 155 died CVD stroke, respectively. hazard deaths was calculated with ratio (HR) 95% confidence interval (95% CI) Cox proportional model. RESULTS Compared normal population, patients diabetes higher stroke (HR, 1.84; CI, 1.33 2.56; HR, 1.82; 1.20 2.76; respectively). Relative subjects no BMI (21 22.9 kg/m(2)), (BMI <21 kg/m(2)) 2.83; 1.57 5.09; 3.27; 1.58 6.76; respectively), while ≥25 increased (p-interaction <0.05). This pattern consistent in sub-populations incidence hypertension. CONCLUSIONS suggests people more critical it people.