Protective effects of taurine against reperfusion-induced arrhythmias in isolated ischemic rat heart.

摘要: The protective effect of taurine (CAS 107-35-7) against reperfusion-induced arrhythmias has been investigated in isolated perfused rat heart (Langendorff method). Partial ischemia was induced by occlusion left descending artery for 15 min, followed 10 min reperfusion. Left ventricular pressure and epicardial ECG were continuously monitored before during A control group submitted to partial without treatment. Three groups ischemia, under (10 mmol/l) treatment the Krebs-Henseleit perfusing buffer only (group 1), at reperfusion 2) throughout experimental period 3). Malondialdehyde levels measured as an index lipid peroxidation muscle damage. incidence irreversible fibrillation significantly diminished from 83% (control group) 36% 1, 42% 2 16% 3. premature beats tachycardia well malondialdehyde decreased results indicate that protects ischemic arrhythmias, via both its properties membrane stabilizer oxygen free radical scavenger.