Genetic factors that affect nonalcoholic fatty liver disease: A systematic clinical review

摘要: AIM: To investigate roles of genetic polymorphisms in non-alcoholic fatty liver disease (NAFLD) onset, severity, and outcome through systematic literature review. METHODS: The authors conducted both specific searches PubMed December 2015 with special emphasis on more recent data (from 2012 onward) while still drawing from historical for background. We identified several that have been most researched and, at this time, appear to the greatest clinical significance NAFLD similar hepatic diseases. These were further investigated assess their effects onset progression mechanisms by which these occur. RESULTS: focus particularly following genes: PNPLA3, p. I148M variant, TM6SF2, E167K variants FTO, LIPA, IFNλ4, iron metabolism, specifically focusing HFE, HMOX-1. discuss effect variations resultant protein its including likelihood cirrhosis hepatocellular carcinoma. While our principal is NAFLD, we also briefly some development severity other diseases, hepatitis C alcoholic disease. results are discussed terms application future potential personalized medicine. CONCLUSION: Polymorphisms factors genes contribute end results. hold keys improvements diagnosis management.