Mechanisms of Vitamin E Regulation: Research Over the Past Decade and Focus on the Future

作者: Elizabeth Parks , Maret G. Traber

DOI: 10.1089/15230860050192189

关键词: BioinformaticsDisease preventionDietary intakeLiver metabolismVitamin E metabolismPreventive healthcareVitamin EAdipose tissue metabolismBiologyAmerican populationBiotechnologyClinical biochemistryCell biologyBiochemistryPhysiologyMolecular biology

摘要: This paper discusses the developments in human vitamin E research since 1990. New methodologies such as use of stable isotopes, advances measurements, and isolation cloning specific alpha-tocopherol binding proteins have facilitated investigation absorption, metabolism, transport humans vivo. Changes food production United States dietary intake impacted availability intake. Epidemiologic therapeutic studies pointed to its role disease prevention healing processes. Specific molecular functions been most recent surprising new findings are an important area for future experimentation. Given aging American population potential preventive medicine, study promises provide some exciting discoveries next decade.

参考文章(52)
Isabelle GARCIA, Matthew RODGERS, Catherine LENNE, Anne ROLLAND, Alain SAILLAND, Michel MATRINGE, Subcellular localization and purification of a p-hydroxyphenylpyruvate dioxygenase from cultured carrot cells and characterization of the corresponding cDNA. Biochemical Journal. ,vol. 325, pp. 761- 769 ,(1997) , 10.1042/BJ3250761
B.T. Burton, W.R. Foster, Health implications of obesity: an NIH consensus development conference Journal of The American Dietetic Association. ,vol. 85, pp. 1117- 1121 ,(1985)
Manfred Schultz, Marcel Leist, Angelika Elsner, Regina Brigelius-Flohé, alpha-Carboxyethyl-6-hydroxychroman as urinary metabolite of vitamin E. Methods in Enzymology. ,vol. 282, pp. 297- 310 ,(1997) , 10.1016/S0076-6879(97)82116-7
John F. Keaney, Daniel I. Simon, Jane E. Freedman, Vitamin E and vascular homeostasis: implications for atherosclerosis The FASEB Journal. ,vol. 13, pp. 965- 975 ,(1999) , 10.1096/FASEBJ.13.9.965
M Schultz, M Leist, M Petrzika, B Gassmann, R Brigelius-Flohé, Novel urinary metabolite of alpha-tocopherol, 2,5,7,8-tetramethyl-2(2’-carboxyethyl)-6-hydroxychroman, as an indicator of an adequate vitamin E supply? The American Journal of Clinical Nutrition. ,vol. 62, ,(1995) , 10.1093/AJCN/62.6.1527S
MG Traber, GW Burton, L Hughes, KU Ingold, H Hidaka, M Malloy, J Kane, J Hyams, HJ Kayden, Discrimination between forms of vitamin E by humans with and without genetic abnormalities of lipoprotein metabolism. Journal of Lipid Research. ,vol. 33, pp. 1171- 1182 ,(1992) , 10.1016/S0022-2275(20)40769-2
M G Traber, D Rader, R V Acuff, R Ramakrishnan, H B Brewer, H J Kayden, Vitamin E dose-response studies in humans with use of deuterated RRR-alpha-tocopherol The American Journal of Clinical Nutrition. ,vol. 68, pp. 847- 853 ,(1998) , 10.1093/AJCN/68.4.847
Lesley F. Tinker, Elizabeth J Parks, Stephen R. Behr, Barbara O. Schneeman, Paul A. Davis, (n-3) Fatty Acid Supplementation in Moderately Hypertriglyceridemic Adults Changes Postprandial Lipid and Apolipoprotein B Responses to a Standardized Test Meal Journal of Nutrition. ,vol. 129, pp. 1126- 1134 ,(1999) , 10.1093/JN/129.6.1126
MG Traber, RJ Sokol, A Kohlschütter, T Yokota, DP Muller, R Dufour, HJ Kayden, Impaired discrimination between stereoisomers of alpha-tocopherol in patients with familial isolated vitamin E deficiency. Journal of Lipid Research. ,vol. 34, pp. 201- 210 ,(1993) , 10.1016/S0022-2275(20)40747-3
Laurent Cavalier, Karim Ouahchi, Herbert J. Kayden, Stephano Di Donato, Laurence Reutenauer, Jean-Louis Mandel, Michel Koenig, Ataxia with Isolated Vitamin E Deficiency: Heterogeneity of Mutations and Phenotypic Variability in a Large Number of Families American Journal of Human Genetics. ,vol. 62, pp. 301- 310 ,(1998) , 10.1086/301699