Feline Immunodeficiency Virus Infection Is Characterized by B7+CTLA4+ T Cell Apoptosis
作者： Mary B. Tompkins , Marta E. Bull , Janet L. Dow , Judith M. Ball , Ellen W. Collisson
DOI: 10.1086/339847
关键词: Antigen-presenting cell 、 Antigen 、 Molecular biology 、 Interleukin 21 、 Cytotoxic T cell 、 IL-2 receptor 、 Feline immunodeficiency virus 、 Biology 、 CD28 、 T cell 、 Immunology
摘要: The B7.1 and B7.2 costimulatory molecules on antigen-presenting cells provide second signals for regulating T cell immune responses via CD28 cytotoxic lymphocyte antigen 4 (CTLA4) cells. proliferation, whereas CTLA4 anergy or apoptosis, terminating the response. Because apoptosis immunodeficiency is a characteristic of feline virus (FIV)-infected cats, it possible that negative signaling B7 may be favored in these cats. Flow cytometry revealed high percentages CD8 + CD4 expressing B7.1, B7.2, lymph nodes FIV-positive cats large fraction coexpressing B7.2. Three-color analysis with anti-B7.1, antiB7.2, anti-CTLA4 TUNEL (terminal deoxynucleotidyl transferase nick-end-labeling) was These data support hypothesis node deterioration FIV-infected results from chronic B7.1- and/or B7.2-CTLA4-mediated T-T interactions.
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S Chakrabarti, K Brechling, B Moss, Vaccinia virus expression vector: coexpression of beta-galactosidase provides visual screening of recombinant virus plaques. Molecular and Cellular Biology. ,vol. 5, pp. 3403- 3409 ,(1985) , 10.1128/MCB.5.12.3403
Wendy Schober, Dorothy E. Lewis, John R. Rodgers, Derek S. Ng Tang, Ahmed Adu-Oppong, Anergy and apoptosis in CD8+ T cells from HIV-infected persons. Journal of Immunology. ,vol. 153, pp. 412- 420 ,(1994)
In-Soo Choi, Stephen M Hash, Barbara J Winslow, Ellen W Collisson, Sequence analyses of feline B7 costimulatory molecules. Veterinary Immunology and Immunopathology. ,vol. 73, pp. 219- 231 ,(2000) , 10.1016/S0165-2427(99)00167-1
Edward A Greenfield, Khuong A Nguyen, Vijay K Kuchroo, None, CD28/B7 costimulation: a review. Critical Reviews in Immunology. ,vol. 18, pp. 389- 418 ,(1998) , 10.1615/CRITREVIMMUNOL.V18.I5.10
C. D. Gimmi, G. J. Freeman, J. G. Gribben, K. Sugita, A. S. Freedman, C. Morimoto, L. M. Nadler, B-cell surface antigen B7 provides a costimulatory signal that induces T cells to proliferate and secrete interleukin 2. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 88, pp. 6575- 6579 ,(1991) , 10.1073/PNAS.88.15.6575
H Golding, G M Shearer, K Hillman, P Lucas, J Manischewitz, R A Zajac, M Clerici, R E Gress, R N Boswell, B Golding, Common epitope in human immunodeficiency virus (HIV) I-GP41 and HLA class II elicits immunosuppressive autoantibodies capable of contributing to immune dysfunction in HIV I-infected individuals. Journal of Clinical Investigation. ,vol. 83, pp. 1430- 1435 ,(1989) , 10.1172/JCI114034
Frank Borriello, Michael P Sethna, Scott D Boyd, A.Nicola Schweitzer, Elizabeth A Tivol, Douglas Jacoby, Terry B Strom, Elizabeth M Simpson, Gordon J Freeman, Arlene H Sharpe, B7-1 and B7-2 Have Overlapping, Critical Roles in Immunoglobulin Class Switching and Germinal Center Formation Immunity. ,vol. 6, pp. 303- 313 ,(1997) , 10.1016/S1074-7613(00)80333-7
Mary B. Tompkins, Gregory K. Ogilvie, Richard A. Franklin, Keith W. Kelley, Wayne A. Tompkins, Induction of IL-2 and lymphokine activated killer cells in the cat Veterinary Immunology and Immunopathology. ,vol. 16, pp. 1- 10 ,(1987) , 10.1016/0165-2427(87)90169-3
Tony Wyss-Coray, Daniela Mauri-Hellweg, Kaspar Baumann, Florence Bettens, Roland Grunow, Werner J. Pichler, The B7 adhesion molecule is expressed on activated human T cells: functional involvement in T-T cell interactions. European Journal of Immunology. ,vol. 23, pp. 2175- 2180 ,(1993) , 10.1002/EJI.1830230919
Vassiliki A. Boussiotis, John G. Gribben, Gordon J. Freeman, Lee M. Nadler, Blockade of the CD28 co-stimulatory pathway: a means to induce tolerance. Current Opinion in Immunology. ,vol. 6, pp. 797- 807 ,(1994) , 10.1016/0952-7915(94)90087-6