An Algorithm for Evaluating Potential Tissue Drug Distribution in Toxicology Studies from Readily Available Pharmacokinetic Parameters
作者： Patrick Poulin , Donna M. Dambach , Dylan H. Hartley , Kevin Ford , Frank-Peter Theil
DOI: 10.1002/JPS.23670
关键词: Drug 、 Algorithm 、 Toxicology studies 、 Distribution (pharmacology) 、 Chemistry 、 Pharmacokinetics 、 In vivo 、 Volume of distribution 、 Bioanalysis 、 ADME
摘要: Having an understanding of drug tissue accumulation can be informative in the assessment of target organ toxicities; however, obtaining tissue drug levels from toxicology studies by …
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