Vitamin A and E deficiency and lung disease in infants with cystic fibrosis

摘要: Objectives Vitamin A and E deficiency is common in cystic fibrosis (CF). These vitamins have immunomodulating properties we determined whether decreased serum vitamin levels young infants are associated with early CF lung disease lower airway inflammation. Methods post-hoc analysis was undertaken on previous data collected prospectively 39 newly diagnosed identified by a newborn screening programme. Assessment of genotype, nutrition, pancreatic status, retinol alpha-tocopherol performed at diagnosis. Pulmonary status clinically, Brasfield chest radiographic scores bacterial counts inflammatory indices bronchial lavage (BL) fluid. assessments were repeated 12 months later. Results At diagnosis, 20 out (51%) had low (mean (SD) 0.7 (0.3) micromol/L) 9/38 (24%) 13.4 (8.4) levels. Dietary energy intake related to concentrations diagnosis (r(2) = 0.27; P 0.001). 1 year, normalized following supplementation. Respiratory symptoms, BL systematically deteriorated during infancy, reaching significance for free neutrophil elastase activity (9 29 vs 21 33; 0.01) IL-8 (79 416; 0.046) No association seen between either or Conclusion We found this birth cohort no evidence implicate the development inflammation infancy.