The synthetic somatostatin analogue, octreotide, ameliorates acute and delayed intestinal radiation injury

摘要: Abstract Purpose: Reducing intraluminal proteolytic activity attenuates intestinal radiation toxicity. This study assessed whether pharmacological inhibition of exocrine pancreatic secretion protects against early and delayed enteropathy in a preclinical rat model. Methods Materials: Rat ileum was sham-irradiated or exposed to 16 once-daily 4.2 Gy fractions X-radiation. Vehicle somatostatin analogue (octreotide, 2 μg/kg/hr) were administered from days prior 10 after the end irradiation. Mucosal injury monitored noninvasively by assessment granulocyte transmigration. Radiation at weeks (early phase) 26 (chronic using quantitative histopathology, immunohistochemistry, morphometry. Results: Octreotide decreased transmigration ( p = 0.0002), attenuated structural 0.04) 0.02), preserved mucosal surface area 0.0008) 0.0008), reduced wall thickening 0.002). did not affect transmigration, histology, controls. Conclusion: These results demonstrate importance consequential mechanisms pathogenesis chronic enteropathy. Short-term octreotide administration ameliorates acute radiation-induced injury, as well changes, should be subject further clinical testing.