New insight into the diagnosis of fastidious bacterial endocarditis.

摘要: Sterile blood cultures are noted in one third of patients with infectious endocarditis. Although half cases this is due to previous antibiotic therapy, the other half, aetiology culture-negative endocarditis intracellular bacteria such as Coxiella burnetii or fastidious growing bacteria. it was previously considered that prevalence organisms identical throughout world, recent investigations on Bartonella clearly showed likely be strongly related epidemiology agent each country. During past decade use molecular techniques PCR subsequent sequencing detect identify valves from have considerably improved aetiological diagnosis. This especially true case following earlier therapy. However, fact DNA remnants can detected some time after acute episode, when patient has been cured, suggests predictive value these along traditional histology and culture need evaluated closely.