Success of Repeat Detrusor Injections of Botulinum A Toxin in Patients with Severe Neurogenic Detrusor Overactivity and Incontinence

摘要: Abstract Objectives: Detrusor injections with botulinum toxin type A are an effective treatment for neurogenic detrusor overactivity, lasting 9–12 months. When the patients develop resistance, subsequent might be less effective. Repeat in severe overactivity and incontinence were studied. Methods: Patients received Botox ® (300 UI) or Dysport (750 injections. Clinical variables: satisfaction, anticholinergics use, mean maximum bladder capacity, continence volume. Cystometric parameters: compliance, cystometric reflex Statistics: Anova, χ 2 -tests; t -tests paired ( p =0.05). Results: Forty-three men 23 women (mean age 38.3 years; duration of lesion 9.2 years) included. The interval between (on average 9–11 months) did not change significantly =0.5594). satisfaction was high use decreased substantially =0.0000). Significant improvements found clinical parameters compliance only at second treatment. incidence contractions reduced. Four had transient adverse events after . Conclusions: as first one. cause repeat is relapse overactive symptoms.