P-glycoprotein: multidrug-resistance and a superfamily of membrane-associated transport proteins.

摘要: The study of multidrug resistance (MDR) in tumor cell lines has led to the discovery plasma membrane P-glycoprotein (Pgp) molecule. This protein functions as an energy-dependent pump for efflux diverse anticancer drugs from MDR cells. It now appears that Pgp-mediated cells do occur human cancers, and they are likely play a role ultimate response patients chemotherapy. Chemosensitizers, compounds able reverse phenotype, have been identified offer exciting possibility improving efficacy some nonresponsive malignancies. Surprisingly, Pgp-like molecules can be found evolutionarily distant species among both eukaryotes prokaryotes. As group, these proteins form superfamily ATP-dependent transport proteins. finding broad implications provides new insights into how living organisms use this fundamental system regulate trafficking across biological membranes.