Gamma histone 2AX (γ-H2AX)as a predictive tool in radiation oncology
作者： Stamatia Pouliliou , Michael I. Koukourakis
DOI: 10.3109/1354750X.2014.898099
关键词: DNA 、 Ionizing radiation 、 Cancer epigenetics 、 Cancer research 、 Pathology 、 Biology 、 DNA damage 、 Radiobiology 、 Programmed cell death 、 Histone 、 Histone H2AX 、 Clinical biochemistry 、 Biochemistry 、 Health, Toxicology and Mutagenesis
摘要: Ionizing radiation cause DNA damage to cells, leading them cell death via double-strand breaks (DSBs) formation. DSBs formation is followed immediately by histone H2AX phosphorylation (γ-H2AX) and multitude repair factors accumulation. Here we present the methods bio-sampling for γ-H2AX detection, in normal cells animal tissues, cancer lines/tissues clinical trials after treatment, alone or combination with other factors. The purpose of this review highlight use γ-H2AX, as a marker assess repair.
sci-hub.se 参考文章(130)
T. Baumgart, G. Klautke, S. Kriesen, S.A. Kuznetsov, D.G. Weiss, R. Fietkau, G. Hildebrandt, K. Manda, Radiosensitizing effect of epothilone B on human epithelial cancer cells. Strahlentherapie Und Onkologie. ,vol. 188, pp. 177- 184 ,(2012) , 10.1007/S00066-011-0029-4
C. Blattmann, S. Oertel, M. Thiemann, K.J. Weber, P. Schmezer, O. Zelezny, R. Lopez Perez, A.E. Kulozik, J. Debus, V. Ehemann, Suberoylanilide hydroxamic acid affects γH2AX expression in osteosarcoma, atypical teratoid rhabdoid tumor and normal tissue cell lines after irradiation Strahlentherapie Und Onkologie. ,vol. 188, pp. 168- 176 ,(2012) , 10.1007/S00066-011-0028-5
Caroline Pathe, Katharina Eble, Daniel Schmitz-Beuting, Boris Keil, Bjoern Kaestner, Maximilian Voelker, Beate Kleb, Klaus J. Klose, Johannes T. Heverhagen, The presence of iodinated contrast agents amplifies DNA radiation damage in computed tomography. Contrast Media & Molecular Imaging. ,vol. 6, pp. 507- 513 ,(2011) , 10.1002/CMMI.453
Benjamin W. Turney, Martin Kerr, Meenali M. Chitnis, Kunal Lodhia, Yong Wang, Johann Riedemann, Mark Rochester, Andrew S. Protheroe, Simon F. Brewster, Valentine M. Macaulay, Depletion of the type 1 IGF receptor delays repair of radiation-induced DNA double strand breaks Radiotherapy and Oncology. ,vol. 103, pp. 402- 409 ,(2012) , 10.1016/J.RADONC.2012.03.009
Paola Porcedda, Valentina Turinetto, Alfredo Brusco, Simona Cavalieri, Erica Lantelme, Luca Orlando, Umberto Ricardi, Antonio Amoroso, Dario Gregori, Claudia Giachino, A rapid flow cytometry test based on histone H2AX phosphorylation for the sensitive and specific diagnosis of ataxia telangiectasia Cytometry Part A. ,vol. 73, pp. 508- 516 ,(2008) , 10.1002/CYTO.A.20566
Sergio Huerta, Xiaohuan Gao, Edward H. Livingston, Payal Kapur, Haizhou Sun, Thomas Anthony, In vitro and in vivo radiosensitization of colorectal cancer HT-29 cells by the smac mimetic JP-1201 Surgery. ,vol. 148, pp. 346- 353 ,(2010) , 10.1016/J.SURG.2010.05.006
Rajani Choudhuri, William DeGraff, Janet Gamson, James B. Mitchell, John A. Cook, Guggulsterone-Mediated Enhancement of Radiosensitivity in Human Tumor Cell Lines Frontiers in Oncology. ,vol. 1, pp. 19- 19 ,(2011) , 10.3389/FONC.2011.00019
Manabu Koike, Jun Sugasawa, Mariko Yasuda, Aki Koike, Tissue-specific DNA-PK-dependent H2AX phosphorylation and γ-H2AX elimination after X-irradiation in vivo Biochemical and Biophysical Research Communications. ,vol. 376, pp. 52- 55 ,(2008) , 10.1016/J.BBRC.2008.08.095
David Cortez, Saritha Guntuku, Jun Qin, Stephen J Elledge, ATR and ATRIP: Partners in Checkpoint Signaling Science. ,vol. 294, pp. 1713- 1716 ,(2001) , 10.1126/SCIENCE.1065521
Noel F. Lowndes, Geraldine W.-L. Toh, DNA Repair: The Importance of Phosphorylating Histone H2AX Current Biology. ,vol. 15, ,(2005) , 10.1016/J.CUB.2005.01.029