作者: P Solal-Céligny , E Lepage , N Brousse , C L Tendler , P Brice
DOI: 10.1200/JCO.1998.16.7.2332
关键词: Neutropenia 、 Follicular lymphoma 、 Surgery 、 Interferon alfa 、 Alpha interferon 、 Gastroenterology 、 Cyclophosphamide 、 Chemotherapy 、 Teniposide 、 Internal medicine 、 Medicine 、 Regimen
摘要: PURPOSETo compare progression-free survival (PFS), overall (OS), and toxicity of a doxorubicin-containing regimen administered alone or in combination with interferon alfa-2b (IFNalpha) patients low-grade follicular lymphoma (FL) poor prognostic factors.PATIENTS AND METHODSTwo hundred sixty-eight advanced-stage FL received cyclophosphamide, doxorubicin, teniposide, prednisone (CHVP) monthly for 6 months, then every 2 months 12 months. After randomization, 242 were evaluated efficacy: 119 CHVP alone, 123 also IFNalpha at dose 5 million units three times weekly 18 months.RESULTSAfter 6-year median follow-up, the treated + showed significantly longer PFS than those who (2.9 years v 1.5 years, respectively; P = .0002) OS (not reached 5.6 .008). Although some side effects, which included neutropenia, asthenia, ...