Engraftment syndrome after allogeneic hematopoietic cell transplantation in adults.

摘要: We performed a retrospective study of the engraftment syndrome (ES) as defined by Spitzer Criteria in adult patients undergoing allogeneic hematopoietic cell transplantation (HCT) for various hematological malignancies at single institution, over decade, and analyzed its relationship to acute GVHD; 217 underwent either myeloablative (38.7%) or reduced intensity (61.3%) HCT; 22.1% met criteria ES. Acute GVHD prophylaxis (P = 0.006) transplants prior 2006 (P < 0.0001) were significantly associated with risk ES univariable analysis. Early aGVHD within 4 weeks was more common compared non cohort (21 vs. 8.3% respectively, P = 0.02). did not predict future GVHD, day +180, cumulative incidences grades II–IV (31 23%, P = 0.19) chronic 2 years (42 36%, P = 0.28) different between groups, respectively. No significant differences NRM, overall survival progression-free observed two groups. Although predictive early aGVHD, occurred independently 79% patients. Survival outcomes should be evaluated larger randomized investigate if there is correlation Am. J. Hematol. 89:698–705, 2014. © 2014 Wiley Periodicals, Inc.