2-(2-phenylethyl)chromones from Chinese eaglewood.
作者： Lin Yang , Lirui Qiao , Dan Xie , Yuhe Yuan , Naihong Chen
DOI: 10.1016/J.PHYTOCHEM.2011.11.017
关键词: Traditional medicine 、 Chromone 、 Neurotoxicity 、 Stereochemistry 、 Viability assay 、 Cell survival 、 Chemistry 、 Thymelaeaceae
摘要: 2-(2-Phenylethyl) chromones and a 2-(2-phenylethenyl) chromone, were isolated from the ethanolic extract of Chinese eaglewood. Their structures determined on basis extensive analyses spectroscopic data. Among those, one showed significant neuroprotective activities against both glutamate-induced corticosterone-induced neurotoxicity in P12 pheochromocytoma human U251 glioma cells at concentration 10 μM increased cell viability by 82.2% 86.9%, respectively.
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